The calcium channel blockers divided into classes
I) Diphenylalkylamines: verapamil.
II) Benzothiazepines: Diltiazem
III)Dihydrophyridines: *Nefedipine
*Amlodipine
*Isradipine
*Nicardipine
*Nisoldipine
MECHANISM OF ACTION
Calcium channel antagonists block the inward movement of calcium by binding to L-type (Long lasting current) calcium channels in the heart and in smooth-muscle of the coronary and peripheral vasculature, thereby dilating the main coronary and systemic arterioles. None of thesd channel blockers interfere with calcium-dependent neurotransmission or hormone release because these processes donot utilize 'L' type channels.
USES
*Angina
*Hypertension
*Supraventricular tachycardia
*Migraine headache
*Preterm labour
*Rayanaud's syndrome
*Stroke
CONTRAINDICATION
*Bradycardia
*Hypotension
*Heart block
*Heart failure
*Cardiogenic shock.
I) Diphenylalkylamines: verapamil.
II) Benzothiazepines: Diltiazem
III)Dihydrophyridines: *Nefedipine
*Amlodipine
*Isradipine
*Nicardipine
*Nisoldipine
MECHANISM OF ACTION
Calcium channel antagonists block the inward movement of calcium by binding to L-type (Long lasting current) calcium channels in the heart and in smooth-muscle of the coronary and peripheral vasculature, thereby dilating the main coronary and systemic arterioles. None of thesd channel blockers interfere with calcium-dependent neurotransmission or hormone release because these processes donot utilize 'L' type channels.
USES
*Angina
*Hypertension
*Supraventricular tachycardia
*Migraine headache
*Preterm labour
*Rayanaud's syndrome
*Stroke
CONTRAINDICATION
*Bradycardia
*Hypotension
*Heart block
*Heart failure
*Cardiogenic shock.
