Monday, September 30, 2013

Tinea capitis


Tinea capitis




Syndrome: Scalp ringworm

Major points
•        Most common in preschool or school-age children (ages 3–9 years)

•        Clinical presentation is an incomplete alopecia especially prominent on the crown and occipital regions, with scaling
 















•        Other clinical presentations:
1. Asymptomatic scaling
2.

Widespread scaling with minimal hair loss (seborrheic dermatitis-like pattern)
3. Black-dot tinea – discrete areas of hair loss with stubs of broken hairs resembling dots
4. Kerion – painful, inflamed, crusted mass with purulent discharge; often with associated fever and regional lymphadenopathy



•        Transmission is person-to-person or fomites such as combs, clothing, bedding, toys and furniture

•Asymptomatic individuals, especially family members, act as reservoirs for infection (~25% of family members affected)

Diagnosis

•        Clinical examination
•        KOH preparation: observe spores within broken-off hairs, rarely hyphae
•        Culture – collect specimen by rubbing a sterile cotton swab over the scalp and inoculating in fungal media
•        Skin biopsy may be necessary to confirm diagnosis

Treatment

•        Topical antifungals not fully effective
•        Oral griseofulvin:
1. Microsize griseofulvin 20mg/kg per day (maximum 1 g/24 hours)
2. Ultramicrosize griseofulvin 10mg/kg per day (maximum 750 mg/24 hours)

Take BID with fatty foods to increase absorption

Minimal duration of treatment is 4–6weeks; continue for 2 weeks past clinical resolution

•        Adjuvant treatment to decrease fungal shedding and spread of infection

1.      Selenium sulfide 2.5% shampoo 2–3 times a week
  1. Ketoconazole 1–2%shampoo2–3 times a week

•        Newer oral antifungal therapies shown to be safe and effective
 terbinafine, itraconazole, fluconazole

•        Obtain follow-up cultures until negative result is obtained

•        Evaluate household contacts and treat if necessary

•        For severe inflammatory kerion: prednisone 1 mg/kg per day in addition to antifungal therapy, can hasten reduction of scaling and pruritus
•        Secondary bacterial infection in a kerion should be treated with appropriate antibiotic therapy for Staphylococcus coverage

Prognosis
•        Usually resolves without permanent alopecia
•        With severe inflammatory disease, scarring and permanent hair loss may occur, but tends to be rare and spotty